Benefits of NMN
Nicotinamide Mononucleotide (NMN) is the new kid on the block when it comes to supplements for longevity and health. First coming to prominence as the result of research by David Sinclair, NMN is quickly becoming one of the most popular supplements to prevent aging and age-related declines in quality of life.
Here we go over some of the benefits of NMN, where to get it, and what dosages are common for NMN supplementation.
Where To Buy NMN
At SprintingWorkouts.com, we have purchased and tested out a variety of NMN supplements to see which provide the best benefits and which ones are bogus.
Through this process, we have concluded that the best NMN supplement on the market is Nootropics Depot NMN.
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Researchers are constantly working to find ways to improve our health and increase longevity. One of the most promising new discoveries is nicotinamide mononucleotide (NMN), a naturally occurring compound found in food and made by the body. NMN has been shown in studies to benefit metabolic health, mitochondria function and neuronal growth, as well as other areas of aging research.
NAD+, a coenzyme that is essential for mitochondrial function, is a key regulator of mitochondrial biogenesis. In addition to its role in energy production, NAD+ also serves as an important signaling molecule. NAD+ levels decrease with age and as a result, mitochondrial function decreases.
NAD+ can be produced through two different metabolic pathways: one producing nicotinamide mononucleotide (NMN) from nicotinamide riboside (NR) and the other producing NMN from nicotinamide phosphoribosyltransferase (NNMT). NMN can then be converted into NAD via NAMPT or directly into NAD+.
NMN May Restore Response To Exercise
According to an article in the scientific journal Cell, decreases in endothelial NAD+ is one of the reasons why our ability to exercise and derive benefits from exercise declines with age.
According to this study, NAD+ and SIRT1 play a role in vascular remodeling in response to exercise. If your NAD levels fall with age, these systems cannot function as well and this leads to declines in your ability to exercise and adapt to exercise.
By taking an NMN supplement, it is possible that you can reverse this blunted response to exercise. For aging athletes, combining NMN with exercise is a potentially powerful combination that can allow you to gain benefits from exercise in a similar way to when you were young.
NMN Improves Skeletal Muscle Health & Function
Nicotinamide Mononucleotide has the potential to enhance the function and health of skeletal muscle, especially in older adults.
With time, muscular function declines, and this is associated with age-related losses in muscle strength, muscle power, both of which are correlated with decreased quality of life and increased risk of fall related injury.
A study in Nature looked at the effects of chronic NMN supplementation on muscular function. The study found the following effects:
- Increased skeletal muscle insulin signaling in response to NMN supplementation, which may help individuals maintain muscle mass.
- Improved muscle strength and performance in older men.
- Significantly increased the levels of NAD+ and NAD+ metabolites in whole blood.
Improves metabolic health
Improved metabolic health is one of the reasons people take NMN supplements. A key benefit of NMN is its ability to improve metabolic health. This includes improving insulin sensitivity, which can help lower blood glucose levels and reduce the risk of type 2 diabetes. In addition, NMN may also help lower blood pressure and cholesterol levels.
Increased energy production and antioxidant protection. NMN provides your body with the building blocks it needs for new cells as well as increased energy production through increased mitochondrial function and protection from oxidative stress.
- Supports exercise endurance & recovery
- NMN helps you stay in shape by boosting endurance and recovery.
Studies show that NMN increases endurance by activating “mitochondrial biogenesis”—the process of creating new mitochondria, or the energy-producing part of your cells. (It also supports muscle growth.)
Improves age-related decline in vision
NMN increases NAD+, which is important for eye health. Increased levels of NAD+ can help prevent age-related macular degeneration and cataracts, according to a study in the journal Science Translational Medicine. It also helps preserve night vision, according to another study in the same journal.
Enhances mitochondrial function
One of the main functions of NMN is to help increase NAD+ levels in the body. NAD+ is a coenzyme that's used by many different enzymes involved in energy metabolism, and it's also important for signaling between cells. As you age, your NAD+ levels decrease, which can have detrimental effects on mitochondrial function.
NAD+ levels are not only important for maintaining healthy mitochondria but also for regulating chromatin structure and DNA repair in general. When these processes don't work properly due to low NAD+, it can lead to dysfunctional organelles like mitochondria or even cell death (apoptosis). The good news is that NMN supplementation has been shown to increase NAD+ levels both in young animals and older ones--and this helps improve overall health as well as longevity!
NMN Supports Brain Health & Neuron Growth
One of the most in-depth studies on NMN was published in Nature Medicine in 2012. The study found that over a 10-month period, mice given NMN were able to improve their learning and memory capabilities. This means that the supplement can help support brain health and neuron growth, potentially protecting against age-related cognitive decline.
While it hasn't been tested on humans yet, there's no doubt that NMN has potential as a treatment for Alzheimer's disease and Parkinson's disease as well. Both of these diseases are caused by damage to neurons; if you can prevent this damage from happening at all via NMN supplementation, your risk of developing either illness will be significantly lower!
- NMN increases longevity, supports aerobic exercise and overall health.
- NMN, or nicotinamide mononucleotide, is a naturally occurring compound found in foods like broccoli and asparagus. It's also present in mushrooms.
- It increases NAD+ levels by converting it into NAD+. In turn, this can lead to increased longevity and metabolic health benefits.
NMN is a potent anti-aging compound that can help you live longer and healthier. It’s been shown to increase NAD+ levels in the body and enhance mitochondrial function, which could be beneficial for your vision, brain health, muscle growth and more. Plus, it can help you exercise longer without getting tired!
Ji, J., Damschroder, D., Bessert, D., Lazcano, P., Wessells, R., Reynolds, C. A., & Greenberg, M. L. (2022). NAD supplementation improves mitochondrial performance of cardiolipin mutants. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867(4), 159094. https://doi.org/10.1016/j.bbalip.2021.159094
Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L. J., Osborne, B., Joshi, S., Lu, Y., Treviño-Villarreal, J. H., Kang, M. J., Hung, T. T., Lee, B., Williams, E. O., Igarashi, M., Mitchell, J. R., Wu, L. E., Turner, N., Arany, Z., … Sinclair, D. A. (2018). Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell, 173(1), 74–89.e20. https://doi.org/10.1016/j.cell.2018.02.008
Igarashi, M., Nakagawa-Nagahama, Y., Miura, M., Kashiwabara, K., Yaku, K., Sawada, M., Sekine, R., Fukamizu, Y., Sato, T., Sakurai, T., Sato, J., Ino, K., Kubota, N., Nakagawa, T., Kadowaki, T., & Yamauchi, T. (2022). Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. npj aging, 8(1), 5. https://doi.org/10.1038/s41514-022-00084-z